Colt Python (Resident Evil)

One of the most powerful handguns in the world, the cylinder has the space for six rounds. It uses Magnum Rounds.

If you play the Advanced/Arranged Mode in the Director's Cut version of the game you can get this weapon with unlimited ammunition. All you need to do is complete the game and save both of your fellow comrades. If playing as Jill, this means saving both Chris and Barry. If playing as Chris, it means saving Jill and Rebecca.