Yawn (Resident Evil)

A snake of gigantic proportions. This terrible demon is one of the first boss fights you encounter in the game, and it takes a large amount of ammunition to scare it away.

You have to be careful though, as not only does this snake cause massive amounts of damage, its fangs are dripping with a poison that cannot be cured with an ordinary Blue Herb. If you do get poisoned, you need special Serum to remedy it. On the second encounter, however, it has somehow lost its ability to poison you, so you just need to focus on keeping your health up and unloading everything you have into it until it dissolves into a puddle of purple goo.