Albert Wesker (Resident Evil 5)

In an attempt to prevent Chris and Sheva from spoiling his plans, he had no choice but to get his hands dirty and deal with them himself. His superhuman abilities and his lightning speed meant he could not be fought in a traditional way, as it is almost impossible to fire a gun at him and land a successful hit. Instead you have to play a game of hide and seek with him, wait until he has lost track of you, and surprise him with a few sneaky shots when he least expects it.