Albert Wesker (Resident Evil 5)

In an attempt to prevent Chris and Sheva from spoiling his plans, he had n choice but to get his hands dirty and deal with them himself. His superhuman abilities and his lightning speed meant he could not be fought in a traditional way, as it is almost impossible to fire a gun at him and land a successful hit. Instead you have to play a game of hide and seek with him, wait until he has lost track of you, and surprise him with a few sneaky shots when he least expects it.