Ozwell E. Spencer (Resident Evil 5)

The last surviving founder of Umbrella, Spencer's ambitions have always been slow-burning. It was over the course of years that he arranged for the death of his fellow founders, James Marcus and Edward Ashford. Time passed, and Spencer became a shell of a man. Reduced to life in a wheelchair, he hid from the icy hand of death in a lonely estate, life prolonged by tubes and wires, tormented by the demons of his past.