Ark is the leading protagonist who begins the game with a case of amnesia. Plagued by a severe headache and nausea, he realised his memory was gone after helicopter crash shown in the introductory sequence. For Ark, the past is shut tightly in the darkness. Thinking about it is like grabbing at fog. It dissipates and is simply...gone. Left alone on a run-down street, the smell of death on the wind, he hopes for someone to come by. There is somebody nearby, but is it friend or foe? His only safeguard is a gun. And it seems that the gun is guiding him. But will it be enough to save him?
Urged on by the sudden death of his predecessor, Vincent is a young, elite member of Umbrella Inc. and acknowledged as the highest authority on the island. While he is a skilful ruler, he is also a brilliant scientist who has been conducting sinister medical experiments on living bodies in his role as Directory of the Umbrella organisation. Aware of these experiments, the main organisation continues its tacit approval.
Thievery, larceny, robbery, assault: Andy used to be scientist, but now that was but a fading memory. Crime did pay. But then he received a call from Umbrella, a big-shot pharmaceutical company. Will he come to work for them? Umbrella, it seems, has been buying up everything. They'd acquired a small European isle, Sheena Island, a backwater with waste disposal facilities so old-fashioned that no-one knew how to fix them. Umbrella Inc. offered the maintenance contract to Andy, a low-life who has racked up crime after crime. Why? Without thinking too much about the corporation's reasoning, seduced by the money, Andy grabbed his suitcase and too up the offer. With barely any possessions but his beloved camera, he set off for a new life. But it didn't take him long to discover Umbrella's sinister secrets.
Lott's father is the head of the Applied Genetic Engineering department at Umbrella, a man who has single-mindedly devoted himself to his research without a thought to his own family. Ever since he could remember, Lott had heard about natural selection and the different attributes people possessed based on the race they were born into. Lott has been deeply influenced by his father and the Umbrella organisation. When the "accident" occurred, perhaps influenced by the brutality of adolescence, Lott believed that "the weak should die." But, after seeing his own parents wiped out by the T-virus, Lott began to understand his own powerlessness as a living being. Wanting to set things right and feeling an overwhelming sense of guilt, he has begun to fight back against everything the Umbrella organisation stands for.