The zombie is the most common enemy in the game, the prison staff and the construction workers of the Rockfort Facility who became infected after the island was bombed and the T-Virus spread. But it doesn't stop there, somehow the workers and scientists at the Antarctic Facility also received the same fate.
The zombie is an easy enemy, as long as they're in small numbers. The Handgun is usually enough to keep them at bay. It's possible to decapitate one or many zombies with a single shotgun blast, simply aim up when they come into grabbing range, and fire.
The zombie dog, unlike the Cerberus, was not an experiment but more of an accident. When exposed to the T-Virus the creature mutates much like any other animal. However, the movements and attacks are practically identical to that of the Cerberus.
The easiest way to deal with these dogs is by using the handgun. Wait until they come at you and fire a single shot. Wait until they stagger to their feet and prepare to pounce, then fire again. Keep repeating until they're dead. The problems come when you're surrounded, as their jumping bite attacks could be fatal if delivered one after the other constantly.
After the T-Virus outbreak, these normal bats have become more vicious.
Like most smaller enemies of the games, it's not worth dealing with these. In fact, the best way to avoid them is to equip your lighter, the light will result in the bats staying away from you.
A monster created from a common earthworm being infected with the T-Virus. As a result it has grown to enormous proportions, large enough to swallow a man whole. Its ability to tunnel through soft soil at tremendous speed, coupled with its ability to detect minor tremors in the ground, it can follow your footsteps on the surface and attack you wherever you tread.
The trick to avoiding its attacks is to stand still until you see it about to burst through the ground where you stand, then quickly move out of the way before it does so. While it is partially submerged, unload your most powerful weapons into its body before it tunnels back down into the ground.
This is the result of injecting the T-Virus into salamanders, and tampering with their DNA. They have an incredible growth rate, and can generate a large electric field several times more powerful than the animal it was based off. This is an infant, and does not possess this power until its fully grown.
Whilst in the Biohazard Containment Room, you see several of these little creature break free and scuttle around. It's best to just avoid these, as they have the ability to shock you but its not very damaging. One manages to escape the room, however, you never encounter it again in this form.
Before he became a zombie, this doctor was into autopsies and weird experiments involving different torture methods. Somehow this makes him a stronger zombie, and much faster.
The Grenade Launcher should be used against this zombie, as dispatching him quickly is the best option.
A different species of spider infected with the T-Virus. Due to their slimmer nature, they move much faster than the Webspinner or Giant Spiders seen in other games. Again, they also have the ability to spit poison.
As well as being faster, they're also much stronger and difficult to kill. The Shotgun or Grenade Launcher should be used against them, but keep them at a distance to avoid their poison.
These variations of the Hunter have a purple tint to their skin. They're more deadly than the regular Hunter, stronger, quicker, and can administer a dose of poison from its venomous claws.
Treat these Sweepers the same way you'd treat a normal Hunter, except try harder to not let it touch you, as being poisoned can really hinder your progress.
Giant Black Widow
The mother of all Black Widows, this regular black widow is the loner who was trapped below the floor in the B.O.W. Room in the Antartic Facility. When the gas leak occured, it grew even more to amazing proportions.
You'll encounter this creature when playing as Chris, however the fight is not mandatory. You can simply avoid it while you get the necessary items and then leave. However, if you're determined to kill it, it can be done with whatever powerful weaponry you have on you, the Grenade Launcher is always good for a boss battle.
A small insect, their DNA was used in the creation of the T-Veronica Virus.
There are thousands of these small insects, and it's better just to avoid them. Run past them, you'll probably receive a few bites, but don't linger.